He made the remarks in a meeting with people from the central Iranian province of Isfahan.
Iran has always witnessed acts of hostility from both major political parties in the US, the Leader added.
According to IRNA, thousands of people from the central Iranian province of Isfahan met here Wednesday with Ayatollah Khamenei at Imam Khomeini Mosque downtown Tehran.
Further details about the meeting will be released later.
EghtesadOnline: The Supreme Leader of the Islamic Revolution Ayatollah Seyyed Ali Khamenei said on Wednesday that the US election results make no difference to Iran.