While the majority of symbol tickers were in the red, some stocks in pharmaceuticals and petrochemical groups closed trading session in positive territory.
Despite bleak summer reports, the price of auto company stocks soared.
The TSE's main index TEDPIX closed Wednesday’s trade at 305,807.6, according to Financial Tribune.
About 2.44 billion shares valued at 10.88 trillion rials ($96.7 million) changed hands at TSE for the day.
Trading at TSE and over-the-counter Iran Fara Bourse starts on Saturday and ends Wednesday.
AzarAb Industries Company was the biggest winner as its shares went up 6.19% to 5,129 rials per share.
Barakat Pharmaceutical Group incurred the biggest loss among all TSE-listed companies and went down 9.22% to 4,381 rials per share.
Mobarakeh Steel Company contributed the most to the benchmark's fall, followed by Tehran Oil Refining Company, Tabriz Oil Refining Company and Kharg Petrochemical Complex.
Pars Petrochemical Company gave the biggest boost to the benchmark index, followed by Nouri Petrochemical Company, Bandar Abbas Oil Refining Company and Persian Gulf Petrochemical Industries Company.
The Price Index lost 671.71 points, or 0.81% to close at 81,935.3.
First Market Index was down 2,112.40 points, or 0.94% to post 222,874.6. Second Market Index was down 3,788.41 points, or 0.61% to reach 619,122.6.
The Industry Index went down 2,298.22 points or 0.83% to register 273,584.8. The Free Float Index was down 3,125.97 points to hit 346,379.23.
TSE 30 went down 111.79 points to settle at 13,529.4 and the TSE 50 ended 99.82 points lower to finish at 12,262.4.
IFX Down 0.57%
Iran Fara Bourse main index IFX lost 21.5 points or 0.57% to close Wednesday trade at 3,783.38.
About 1.25 billion securities valued at 6.87 trillion rials ($61.10 million) were traded at the over-the-counter exchange for the day.
Daroupakhsh Distribution Company registered highest trade value as 634.964 billion rials ($5.64 million) worth of its shares changed hands.
Hormozgan Steel Company, Esfahan Steel Company, Iran Fara Bourse and Shiraz Oil Refining Company had the most negative impact on IFX.
Marun Petrochemical Complex gave the biggest boost to IFX, followed by Damavand Power Generation Company, Pasargad Insurance Company and Daroupakhsh Distribution Company.