The maiden flight departed from Mashhad International Airport in a ceremony attended by provincial officials and representatives of Azerbaijan Republic in Iran.
The weekly flights are operated by an Azerbaijani airline on Mondays and Thursdays.
Amani-Bani said the frequency of flights may increase to run daily in the future, according to Financial Tribune.
The new flights have been launched with the aim of strengthening Iran-Azerbaijan relations and facilitating Azerbaijani Muslims’ pilgrimage to Mashhad, which is home to the holy shrine of eighth Shia Imam Reza (PBUH).
Amani-Bani expects that with the launch of the new route, more than 3,000 Azeri Shia pilgrims will visit Mashhad every month, Mehr News Agency reported.